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Unwanted side effects of thalidomide can include drowsiness, fatigue, severe constipation, and painful nerve harm ( neuropathy ). The neuropathy will be extreme, and might not go away after the drug is stopped. Due to this fact, further analysis into the costs of lenalidomide maintenance therapy (with or without extra therapies) is warranted.
Take into account simply the co-payments for medicine like lenalidomide (Revlimid) and bortezomib (Velcade), which might high $1,000 a month. Excessive-dose chemotherapy (Melphalan) combined with transplantation of haematopoietic stem cells will increase the speed of full remission and extends occasion-free and overall survival.
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Due to the relative modest activity in closely pretreated patients, other alternate options in first-line therapy, and potential for all times-threatening tumor flare and different toxicity with lenalidomide, this agent should not be used outdoors the setting of a effectively-deliberate clinical trial.